Sequence-Dependent Elongation Dynamics on Macrolide-Bound Ribosomes
نویسندگان
چکیده
منابع مشابه
Sequence-dependent elongation dynamics on macrolide-bound ribosomes.
The traditional view of macrolide antibiotics as plugs inside the ribosomal nascent peptide exit tunnel (NPET) has lately been challenged in favor of a more complex, heterogeneous mechanism, where drug-peptide interactions determine the fate of a translating ribosome. To investigate these highly dynamic processes, we applied single-molecule tracking of elongating ribosomes during inhibition of ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2014
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2014.04.034